Cardiac Surgery Research

Clinical Research

Using the Department Aortic Surgery Database several projects of outcome analysis have been performed addressing different aortic pathologies and operations and using complex statistical analysis. Those analyses have resulted to date in several papers accepted in peer-reviewed journals and abstracts presented at national and international meetings.

Development of The Cornell International Consortium for research in Aortic Surgery

This is a network of high quality – high volume aortic centers who utilize blinded external analysis of the data by a dedicated group of experts for outcome analysis.

Study of the flow dynamics in the aortic root

Two major research projects investigating the flow dynamics in the aortic root after valve sparing operations in an animal model and in humans are actually being completed in collaboration with the European Hospital in Rome, the ForeCardioLab in Milan and the Universita’ La Sapienza in Rome. This research activity use 4D-MRI, computational dynamics and sophisticated in vitro simulators to study the flow in the aortic root.

Development of the Radial Artery Database International Alliance

This project was conceived to overcome the limitations of the single studies published to date on the radial artery and to create a joined database including all the major RCTs and propensity matched observational studies. This joined database will allow sufficient statistical power to perform the first patient-level meta-analysis to evaluate the clinical benefits related to the use of the radial artery. If successful this project will be the first to show a RCT-based survival benefits with the use of a second arterial conduit during coronary artery bypass operations.

Study of the spinal cord circulation and validation of spinal near infrared spectroscopy

The efficacy of spinal near infrared spectroscopy in reflecting the changes in spinal cord circulation is being investigated in a pig model and in clinical practice.

Study of the distribution of retrograde brain perfusion

The flow distribution of retrograde cerebral perfusion during operations on the aortic arch in deep hypothermic circulatory arrest is being investigated using highly specific neuronal markers.